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    The little blue pill may not have ever been if not for one dutiful nurse. Viagra, Pfizer’s blockbuster erectile dysfunction drug hit the market in 1998. In 20 years, it’s become ubiquitous: 62 million men all over the world have bought the drug, according to a Pfizer spokesperson. The US military shells out $41.6 million per year for it, and from 2012 onward, the US, Mexico, and Canada spent about $1.4 billion on it annually (although those numbers are projected to fall in the coming years when Pfizer’s patent on the drug expires in 2020). Despite the drug’s popularity today, the researchers who discovered it weren’t even looking for it. Sildenafil, the active ingredient in Viagra, was originally developed to treat cardiovascular problems. It was meant to dilate the heart’s blood vessels by blocking a particular protein called PDE-5. Viagra (sildenafil) and Levitra (vardenafil) are prescription medications used to treat erectile dysfunction and pulmonary arterial hypertension. Viagra was introduced by Pfizer Pharmaceuticals in March 1998 as a treatment for pulmonary arterial hypertension. The clinical trials revealed that the active ingredient — generically known as sildenafil citrate — also relaxed the muscle tissues in the penis, allowing for increased blood flow. Levitra, introduced in 2003 by Bayer Pharmaceuticals and marketed by Glaxo Smith Kline to treat erectile dysfunction, works similarly. In appearance, Viagra tablets are blue, rounded diamonds that are available in 25 mg, 50 mg, and 100 mg doses. Levitra has orange-colored tablets in 2.5 mg, 5 mg, 10 mg, and 20 mg doses. It is recommended that both medications be taken 30 to 60 minutes before sexual activity is intended.

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