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    Prednisolone and prednisone are integral components of induction and maintenance immunosuppressive regimens in solid organ transplantation. The pharmacokinetics of these agents are extremely complex. Prednisolone is the active drug moiety while prednisone is both a pro-drug and inactive metabolite of prednisolone. Within the dosage range used in transplantation, prednisolone and prednisone exhibit concentration-dependent non-linear pharmacokinetics when parameters are measured with reference to total drug concentration. Dose dependency disappears when free (unbound) prednisolone is measured. Altered organ function, changing biochemistry and use of a number of concomitant medicines in transplantation appear to lead to pharmacokinetic differences in transplant recipients compared with other patient groups. Greater than threefold variability in dose-adjusted exposure to total prednisolone in transplant recipients is evident. order ciprofloxacin 500mg The growth of knowledge in the field of the pharmacokinetics of prednisolone/prednisone has been slow for several reasons. First, convenient and specific methods for measuring these steroids only became available with the development of high performance liquid chromatographic methods. Secondly, prednisolone is nonlinearly bound to transcortin and albumin: since the unbound concentrations of prednisolone are biologically relevant, it was necessary to determine the free fraction in each plasma sample. Thirdly, due to the short half-life of prednisolone no steady-state is achieved, and therefore area under the concentration-time curve needed to be determined in all studies. Fourthly, prednisolone and prednisone are interconvertible and prednisolone is given intravenously as an ester prodrug, features which created controversies about the correct interpretation of pharmacokinetic results. Finally, the total body clearances of total and (to a lesser degree) of unbound prednisolone increase with increasing concentrations of prednisolone. Therefore, in order to compare pharmacokinetic results between different subjects, standardised doses had to be administered.

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    The contents of this page have been copied to Talk: List_of_drugs. I (User: Matt Kingston) am in the process of creating a list of drugs and their various names. The list will be alphabetical and will use the following format (subject to change if better suggestions are put forward). All items in the list will follow the general format: ===Name of drug=== *Will be capitalized if it is a trade name (brand name) or uncapitalized if it is a generic name. *Two trade names that are nearly identical (eg Adalat PA and Adalat XL) need not have separate entries unless there is a particular reason for doing so. *Names will be listed alphabetically and broken into an appropriate number of pages (with 200-500??? items per page) Peg-Intron is the correct spelling that you have listed as Pegetron for pegylated interferaon alfa2b made by schering plough and marketed in the US for HCV (This list is an example only and may not be accurate.) 1,25 dihydroxycholecalciferol1-Day1-deamino-8-d-arginine vasopressin13-cis-retinoic acid2'-deoxycoformycin2-amino-6-mercaptopurine2-amino-6-trifluoromethoxy-benzothiazole2-Cd A2-chlorodeoxyadenosine2-PAM2-propylpentanoic acid2-propylvaleric acid2-pyridine aldoxime methochloride292 MEP311C903M Avagard (Discontinued)3M Cavilon Skin Cleanser3TC4-demethoxydaunorubicin4-dmdr4-hydroxybutyrate4-methylpyrazole4-MP4-Way Longcting40 Winks (Discontinued)5-aminosalicyliccid5-ASA5-FC5-fluorouracil5-flurocytosine5-formyl tetrahydrofolate5-FU6-mercaptopurine6-MP6-TG6-thioguanine642 Tablet8-arginine vasopressin8-MOP9-beta-D-ribofuranosyladenine9a-fluorohydrocortisonea-2-interferon A-200A-Caro-25A-Hydro Cort A-methapred A-Spas (Discontinued)A. (Discontinued)Camalox Suspension Tablet (Discontinued)Camila Campathcampath-1HCampho-Pheniquecamphor and phenolcamphor, menthol, and phenolcamphorated tincture of opium Camptosar Canasa CANCERCancidascandesartancandesartan and hydrochlorothiazide Candida albicans (Monilia)CANDIDIASISCandin Candistatin Canesten Topical Canesten Vaginal Cankaid CANKER SORECantharone (Discontinued)Cantharone Plus (Discontinued)Cantil Capastat Sulfatecapecitabine Capex Capital and Codeine Capitrol Capoten Capozidecapreomycin Capsagelcapsaicincaptoprilcaptopril and hydrochlorothiazide Capzasin-HPCapzasin-P (Discontinued)Carac Carafatecarbacholcarbacholinecarbamazepinecarbamidecarbamide peroxidecarbamylcholine chloride Carbastat Carbatrol Carbaxefed DM RFCarbaxefed RFcarbenicillincarbetapentane and chlorpheniraminecarbetapentane tannate and chlorpheniramine tannatecarbetocin (Canada only)carbidopacarbidopa and levodopacarbidopa, levodopa, and entacaponecarbinoxamine and pseudoephedrinecarbinoxamine, pseudoephedrine, and dextromethorphan Carbiset Tablet (Discontinued)Carbiset-TR Tablet (Discontinued)Carbocaine Carbodec Syrup (Discontinued)Carbodec Tablet (Discontinued)Carbodec TR Tablet (Discontinued)carbol-fuchsin solutioncarbolic acid Carbolithcarboplatincarbopol 940 (Canada only)carboprost tromethamine Carbopticcarbose dcarboxymethylcellulosecarboxymethylcellulose sodium CARCINOMACardem (Discontinued)Cardene Cardene I. Cardene SRCARDIAC DECOMPENSATIONCardilate (Discontinued)Cardio-Green (Discontinued)CARDIOGENIC SHOCKCARDIOMYOPATHYCardioquin (Discontinued)Cardizem Cardizem CDCardizem Injection (Discontinued)Cardizem LACardizem SRCardura Carimunecarindacillincarisoprodatecarisoprodolcarisoprodol and aspirincarisoprodol, aspirin, and codeine Carmol 10Carmol 20Carmol 40Carmol Deep Cleaning Carmol-HCcarmustine Carnation Instant Breakfast Carnitor Caroid (Discontinued)Carrington Antifungalcarteolol Carter's Little Pills (Discontinued)Cartia XTCartrol Oralcarvedilol Casodexcaspofungincaspofungin acetate Castellani paintcastor oil Cataflam CATAPLEXYCatapres Catapres-TTS-1Catapres-TTS-2Catapres-TTS-3CATARACTCatarase 00 (Discontinued)Cathflo Activase Caverject CBDCACCNUCDDPCebid (Discontinued)Ceclor Ceclor CDCecon Cedax Cedilanid-D Injection (Discontinued)Cedocard-SRCee NUCeepryn (Discontinued)cefaclorcefadroxil Cefadyl (Discontinued)Cefanex (Discontinued)cefazolincefdinircefditorencefditoren pivoxilcefepimecefixime Cefizox Cefobid (Discontinued)Cefotancefotaximecefotetancefoxitincefpodoximecefprozilceftazidimeceftibuten Ceftin Ceftin Tablet 125 mg (Discontinued)ceftizoximeceftriaxonecefuroxime Cefzil Cel-U-Jec Celebrexcelecoxib Celectol (Discontinued)Celestoderm-EV/2Celestoderm-VCelestone Celestone Phosphate Celestone Soluspan Celexa CELIAC DISEASECell Cept Cellufreshcellulose sodium phosphatecellulose, oxidized Celluvisc Celontin Cena-K (Discontinued)Cenestin Cenocort A-40 (Discontinued)Cenocort Forte (Discontinued)Cenolate Centrax Capsule Tablet (Discontinued)Centrum Centrum Kids Rugrats Complete Centrum Kids Rugrats Extra CCentrum Kids Rugrats Extra Calcium Centrum Performance Centrum Silver Cepacol Anesthetic Troches Cepacol Maximum Strength Cepacol Mouthwash/Gargle Cepacol Viractin Cepastat Cepastat Extra Strength Cephadyncephalexincephalothincephradine Cephulac (Discontinued)Ceporacin Ceptaz (Discontinued)CEREBRAL PALSYCEREBROVASCULAR ACCIDENT (CVA)Cerebyx Ceredase Cerespan (Discontinued)Cerezyme Cerose-DMCertain Dri Cerubidine Cerumenex Cervidil Vaginal Insert CESCesamet (Discontinued)Ceta-Plus Cetacaine Cetacort Cetafen Cetafen Extra Cetamide Cetane (Discontinued)Cetapred Ophthalmic (Discontinued)cetirizinecetirizine and pseudoephedrinecetrorelixcetrorelix acetate Cetrotidecetylpyridiniumcetylpyridinium and benzocainecetylpyridinium chloride and benzocaine Cevalin (Discontinued)Cevi-Bidcevimelinecevimeline hydrochloride CFDNCGCGP 57148BCGP-42446Charcadole Charcadole Aqueous Charcadole TFSCharcoaid (Discontinued)charcoal Charcocaps Chealamide (Discontinued)Chemet Chenix Tablet (Discontinued)Cheracol Cheracol DCheracol Plus Cheratussin DACChibroxin (Discontinued)CHICKENPOXchickenpox vaccine Chiggerex Chiggertox Children's Dimetapp Elixir Cold Allergy Children's Hold (Discontinued)Children's Kaopectate (reformulation)Children's Sudafed Cough Cold Children's Tylenol Cold Children's Tylenol Sinuschildren's vitamins Chirocaine Chlo-Amine Oral (Discontinued)Chlor-Pro Injection (Discontinued)Chlor-Rest Tablet (Discontinued)Chlor-Trimeton Chlor-Trimeton Allergy DChlor-Trimeton Syrup (Discontinued)Chlor-Tripolon Chlor-Tripolon NDChlorafed Liquid (Discontinued)chloralchloral hydratechlorambucilchloramphenicol Chlora Prep Chlora Prep (Discontinued)Chloraseptic Gargle Chloraseptic Mouth Pain Spray Chloraseptic Rinse Chloraseptic Spray Chloraseptic Spray for Kids Chlorate Oral (Discontinued)chlordiazepoxidechlordiazepoxide and amitriptylinechlordiazepoxide and clidinium Chloresium Chlorgest-HD Elixir (Discontinued)chlorhexidine gluconatechloroethane Chlorofon-A Tablet (Discontinued)Chloromag Chloromycetin Cream (Discontinued)Chloromycetin Kapseals (Discontinued)Chloromycetin Ophthalmic (Discontinued)Chloromycetin Otic (Discontinued)Chloromycetin Palmitate Oral Suspension (Discontinued)Chloromycetin Parenteralchlorophylinchlorophyllchloroprocaine Chloroptic Ophthalmic Solution (Discontinued)Chloroptic SOP (Discontinued)Chloroptic-P Ophthalmic (Discontinued)chloroquine phosphate Chloroserpine (Discontinued)Chlorostatchlorothiazidechloroxine Chlorphed (Discontinued)Chlorphed-LA Nasal Solution (Discontinued)chlorpheniraminechlorpheniramine and acetaminophenchlorpheniramine and carbetapentanechlorpheniramine and hydrocodonechlorpheniramine and phenylephrinechlorpheniramine and pseudoephedrinechlorpheniramine, ephedrine, phenylephrine, and carbetapentanechlorpheniramine, hydrocodone, phenylephrine, acetaminophen, and caffeinechlorpheniramine, phenylephrine, and codeinechlorpheniramine, phenylephrine, and dextromethorphanchlorpheniramine, phenylephrine, and methscopolaminechlorpheniramine, phenylephrine, and phenyltoloxaminechlorpheniramine, pseudoephedrine, and codeinechlorpheniramine, pseudoephedrine, and methscopolaminechlorpheniramine, pyrilamine, and phenylephrinechlorpromazinechlorpropamide Chlortab (Discontinued)chlorthalidonechlorthalidone and atenololchlorthalidone and clonidinechlorzoxazone Cholac Cholan-HMB (Discontinued)Cholebrinecholecalciferol Choledyl (Discontinued)Choledyl SA (Discontinued)CHOLELITHIASIScholera vaccine (all products) (Discontinued)CHOLESTASIScholestyramine resincholine magnesium trisalicylate CHOLINESTERASE INHIBITOR POISONINGCholografin Meglumine Choloxin (Discontinued)chondroitin sulfate-sodium hyaluronate Chooz Chorex (Discontinued)choriogonadotropin alfachorionic gonadotropin (human)chorionic gonadotropin (recombinant)CHORIORETINITISChoron (Discontinued)Chromagen OBchromium injection CHROMOBLASTOMYCOSISCHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)Chronovera Chronulac (Discontinued)Chymex (Discontinued)Cibacalcin (Discontinued)ciclopiroxcidofovircilastatin and imipenemcilazapril (Canada only)cilostazol Ciloxancimetidine Cinobaccinoxacin Cipralan (Discontinued)Cipro Cipro HC Otic Cipro XRciprofloxacinciprofloxacin and hydrocortisone CIRRHOSIScisapridecisatracuriumcisplatin CISPLATIN TOXICITYcitalopramcitalopram hydrobromide Citanest Forte Citanest Plain Cithalith-S Syrup (Discontinued)Citracal Citracal Prenatal Rxcitrate of magnesiacitric acid and d-gluconic acid irrigantcitric acid and potassium citratecitric acid bladder mixturecitric acid, sodium citrate, and potassium citrate Citro-Mag Citro-Nesia Solution (Discontinued)Citroteincitrovorum factor Citrucel Cl-719CLAcladribine Claforan Claravis Clarinex Claripelclarithromycin Claritin [US-OTC/Can]Claritin Extra Claritin Redi Tabs Claritin-D 12-Hour Claritin-D 24-Hour CLAUDICATIONclavulanate potassium and amoxicillinclavulanic acid and ticarcillin Clavulin Clear Away Disc (Discontinued)Clear By Design Gel (Discontinued)Clear Eyes Clear Eyes ACRClear Tussin 30 (Discontinued)Clearsil Maximum Strength (Discontinued)clemastine Clenia Cleocin Cleocin HCl Cleocin Pediatric Cleocin Phosphate Cleocin Tclidinium and chlordiazepoxide Climacteron Climara Clinac BPOClindagel Clindamaxclindamycinclindamycin and benzoyl peroxide Clindets Clindex (Discontinued)Clindoxyl Gel Clinorilclioquinol (all products) (Discontinued)clioquinol and flumethasone (Canada only)clioquinol and hydrocortisone Clistin Tablet (Discontinued)clobazam (Canada only)clobetasol Clocort Maximum Strengthclocortolone Clocream Clodermclodronate disodium (Canada only)clofazimine Clomidclomipheneclomipramine Clonapamclonazepamclonidineclonidine and chlorthalidoneclopidogrel Clopixol Clopixol Depot Clopixol-Acuphase Clopra (Discontinued)clorazepate Clorpactin WCS-90Clorpactin XCB Powder (Discontinued)Clotrimadermclotrimazoleclotrimazole and betamethasonecloxacillin Cloxapen (Discontinued)clozapine Clozaril Clysodrast (Discontinued)CMV RETINITISCMV-IGIVCO Clomipramine CO Temazepam Co-Gesic Co-Pyronil 2 Pulvules (Discontinued)co-trimoxazole Co Actifedcoagulant complex inhibitorcoagulation factor VIIacoal tarcoal tar and salicylic acidcoal tar, lanolin, and mineral oil Cobal Cobalasine Injection (Discontinued)Cobex (Discontinued)Cobolin-Mcocaine COCCIDIOIDOMYCOSIScod liver oil Codafed Expectorant Codafed Pediatric Expectorant Codamine (Discontinued)Codamine Pediatric (Discontinued)Codehist DH (Discontinued)codeinecodeine and acetaminophencodeine and aspirincodeine and butalbital compoundcodeine and guaifenesincodeine and promethazine Codeine Contincodeine, guaifenesin, and pseudoephedrinecodeine, promethazine, and phenylephrine Codiclear DHCodimal Expectorant (Discontinued)Codimal-A Injection (Discontinued)Cogentin Cognex Colacecolaspase Colax-CColazal Col Benemid (Discontinued)colchicinecolchicine and probenecid Cold Allergy Elixir (Discontinued)COLD SOREColdlac-LA (Discontinued)Coldloc (Discontinued)colesevelam Colestidcolestipol Colhist Solutioncolistimethate COLITISCOLITIS (ULCERATIVE)COLLAGEN DISORDERScollagen implantscollagenase Colocort COLONIC EVACUATIONColy-Mycin MColy-Mycin S Oral (Discontinued)Coly-Mycin S Otic Colyte Combantrin Combi Patch Combipres Combivent Combivir Comfort Ophthalmic (Discontinued)Comfort Tears Solution (Discontinued)Comhist Comhist LA (Discontinued)Commit Compazinecompound Ecompound Fcompound SCompound WCompound W One Step Wart Remover Compoz Nighttime Sleep Aid Compro Comtan Comtrex Maximum Strength Sinus and Nasal Decongestant Comtrex Non-Drowsy Cold and Cough Relief Comvax Conceptrol Concerta Condyline CONDYLOMA ACUMINATUMCondylox Conex (Discontinued)CONGENITAL SUCRASE-ISOMALTASE DEFICIENCYCongess Jr (Discontinued)Congess Sr (Discontinued)Congest Congestac Congestant D (Discontinued)CONGESTION (NASAL)CONGESTIVE HEART FAILURE (CHF)conjugated estrogen and methyltestosteroneconjugated estrogens CONJUNCTIVITIS (ALLERGIC)CONJUNCTIVITIS (BACTERIAL)CONJUNCTIVITIS (VERNAL)Conray Constant-T Tablet (Discontinued)Constilac CONSTIPATIONConstulose Contac Cold 12 Hour Relief Non Drowsy (Discontinued)Contac Cough Formula Liquid (Discontinued)Contac Cough, Cold and Flu Day Night Contac Severe Cold and Flu/Non-Drowsy CONTRACEPTIONControl (Discontinued)Control-L (Discontinued)Contuss (Discontinued)Contuss XT (Discontinued)Copaxone (Discontinued)Copegus Cophene XP (Discontinued)Cophene-B (Discontinued)copper injection COPROPORPHYRIACordarone Cordran Cordran SPCoreg Corgard Corgonject (Discontinued)Coricidin Corliprol (Discontinued)Corlopam Cormax CORNEAL EDEMACorrectol Cort-Dome Corta Gel Cortaid Maximum Strength Cortaid Ointment (Discontinued)Cortaid with Aloe Cortatrigen Otic (Discontinued)Cortef Suspension (Discontinued)Cortef Tablet Cortenema (Discontinued)Corticainecorticotropin Cortifoam Cortimyxincortisone acetate Cortisporin Cream Cortisporin Ointment Cortisporin Ophthalmic Cortisporin Otic Cortisporin Topical Cream (Discontinued)Cortisporin-TC Otic Cortizone-10Cortizone-5Cortoderm Cortone Cortone (Discontinued)Cortrophin-Zinc (Discontinued)Cortrosyn Corvert Coryphen Codeine Cosmegen Cosoptcosyntropin Cotazym Cotazym (Discontinued)Cotazym-S (Discontinued)Cotrim (Discontinued)Cotrim DS (Discontinued)COUGHCoumadin Covan Covera Covera-HSCoversylcoviracil Cozaar CPMCreo-Terpin Creomulsion Cough Creomulsion for Children Creon 10Creon 20Creon 25Creon 5Crestor Cresylate Crinone Critic-Aid Skin Care Criticare HNCrixivan Cro Fab [Ovine]CROHN DISEASECrolomcromoglicic acidcromolyn sodium Crossealcrotaline antivenin, polyvalentcrotamiton CROUPcrude coal tar Cruex CRYPTOCOCCOSISCRYPTORCHIDISMCrysellecrystalline penicillin Crystamine (Discontinued)Crysti 1000 (Discontinued)Crysticillin A. (Discontinued)Crystodigin (Discontinued)CSPCTXCuprimine CURARE POISONINGCurosurf CUSHING SYNDROMECUSHING SYNDROME (DIAGNOSTIC)Cutar Cutivate CYAcyanide antidote kit CYANIDE POISONINGcyanocobalamincyanocobalamin, folic acid, and pyridoxine Cyanoject (Discontinued)cyclandelate Cyclessa CYCLOSERINE POISONINGcyclobenzaprine Cyclocort Cyclogyl Cyclomen Cyclomydril Ophthalmiccyclopentolatecyclopentolate and phenylephrinecyclophosphamide CYCLOPLEGIAcycloserine Cyclospasmol (Discontinued)cyclosporin Acyclosporine Cycofed Pediatric (Discontinued)Cycrin 10 mg Tablet (Discontinued)Cyklokapron Cylate Cylert Cylex Cyomin (Discontinued)cyproheptadinecyproterone (Canada only)cyproterone and ethinyl estradiol (Canada only)Cystadane Cystagoncysteaminecysteine CYSTIC FIBROSISCYSTINURIACystistat CYSTITIS (HEMORRHAGIC)Cystografin Cystospaz Cystospaz-MCYTCytadrencytarabinecytarabine (liposomal)Cyto Gam CYTOMEGALOVIRUScytomegalovirus immune globulin (intravenous-human)Cytomel Cytosar Cytosar-Ucytosine arabinosine Cytotec Cytovene Cytoxan Cytra-3Cytra-Kd-3-mercaptovalined-alpha tocopherol D-Amp (Discontinued)d-isoephedrined-mannitol D-Med Injection (Discontinued)D-Pan (Discontinued)d-penicillamine D-S-SD-S-S Plus (Discontinued)D-Vi-Sold-xylose D. The record of each investigation shall be maintained for at least 2 years after distribution of the drug has been completed or 1 year after the expiration date of the drug, whichever is longer. If a cancellation fee is imposed the nonrefundable amount for each aid and accessories cannot exceed 10% of the purchase price of the hearing aid and accessories or $150.00 per aid and accessories, whichever is less. Code § 21.284b (relating to prescribing, administering and dispensing controlled substances). An investigation of each complaint shall be made in accordance with § 25.16(8) (relating to production and control procedures). 30 Day Money Back Guarantee: If a hearing aid is returned within 30 days of date of delivery in the same condition, ordinary wear and tear excluded, you are entitled to a refund of the portion of the purchase price of the hearing aid and accessories as itemized on the receipt and above, less the cancellation fee stated above. Code § 561.1 (relating to drugs and biologicals); 28 Pa. Code § 601.3 (relating to requirements for home health care agencies); and 49 Pa. Records shall be maintained of all written and oral complaints regarding each product. NOTHING IN THIS DISCLOSURE AGREEMENT SHALL RELIEVE A REGISTRANT OF THE OBLIGATION TO REFUND ALL OR PART OF THE ABOVE FEES, INCLUDING THOSE LISTED AS NOT REFUNDABLE, IF A COURT DETERMINES THAT THE REGISTRANT HAS VIOLATED A PENNSYLVANIA CONSUMER PROTECTION LAW IN THE SALE OR FITTING OF THE HEARING AID (OR SIMILAR DEVICE) AND IF THE COURT ORDERS SUCH REFUND. (3) When the drug is marketed in the dry state for use in preparing a liquid product, the labeling shall bear expiration information for the reconstituted product as well as an expiration date for the dry product. IF PART B IS NOT COMPLETED, IT IS BECAUSE A HEARING AID WAS NOT RECOMMENDED OR NOT DESIRED. (4) Recorded and maintained in such manner that the stability data may be utilized in establishing product expiration dates. (2) Expiration dates shall be related to appropriate storage conditions stated on the labeling wherever the expiration date appears. PART B (CANCELLATION FEES THAT WILL BE INCURRED IF A HEARING AID IS RETURNED UNDER THE 30-DAY MONEY BACK GUARANTEE BELOW), WAS COMPLETED AND EXPLAINED AFTER SERVICES WERE PROVIDED AND BEFORE ANY PAYMENT WAS MADE. (3) Determined on any dry drug product that is to be reconstituted at the time of dispensing, as directed in its labeling, as well as on the reconstituted product. (1) Expiration dates appearing on the drug labeling shall be justified by readily available data from stability studies such as described in § 25.21 (relating to stability). This shall be in 10 point type or larger, and may be made out on more than one sheet of paper, but shall employ the following format or be on a form approved by the Department: (date), BEFORE ANY SERVICES WERE PROVIDED. (2) Determined on products in the same container closure systems in which they are marketed. To assure that drug products liable to deterioration meet appropriate standards of identity, strength, quality, and purity at the time of use, the label of all such drugs shall have suitable expiration dates which relate to stability tests performed on the products. (3) A material, compound, mixture or preparation which contains any quantity of the following hallucinogenic substances, their salts, isomers, and salts of isomers, unless specifically excepted, whenever the existence of the salts, isomers, and salts of isomers is possible within the specific chemical designation: (i) 3,4-methylenedioxy amphetamine. Before the provision of any service incidental to or connected with the potential sale of a hearing aid, the registrant shall provide a disclosure agreement and money back written guarantee to the prospective hearing aid user or authorized representative, and shall explain it in detail in accordance with subsection (c).

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