Zoloft (sertraline) is a medication that's frequently prescribed to treat a number of different psychiatric disorders including depression, obsessive-compulsive disorder, and social anxiety disorder. It's also often prescribed for people who've been diagnosed with panic disorder, a condition that causes frequent episodes of specific symptoms call panic attacks. If your doctor suggests you take Zoloft as part of a treatment plan for panic disorder, it can be helpful to learn how the drug might work to help you manage your symptoms. The more you understand about any medication you take, including how it affects the body and any potential side effects it might cause, the more comfortable you're likely to feel about taking it. The generic form of Zoloft, sertraline, has been used to treat anxiety orders since the mid-1990s. 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Zoloft is a selective serotonin reuptake inhibitor (SSRI) that is prescribed to control the symptoms of major depressive disorder, also known as unipolar disorder. This mental disorder is characterized by a persistent low mood and self-esteem and a loss of interest in activities that you once found to be enjoyable. Increased absenteeism from work or school, feeling sad most days, change in appetite, sleeping too much or not enough, and have a lack of energy, or you may even feel like harming yourself. In the brain, once a neurotransmitter has sent its neural pulse, it is usually reabsorbed. As a selective serotonin reuptake inhibitor, Zoloft or generic Sertraline slows down the reabsorption (reuptake) of serotonin in order to extend the length of time this neurotransmitter remains active in your brain which helps to improve your mood as it stabilizes. Serotonin is one of many neurotransmitters produced in your body. 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