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Low Prices our RN at Pacific Center for Plastic Surgery explains how to place a Clonidine Patch on prior to having facial surgery. Clonidine Patch - Clinical Pharmacology. Clonidine stimulates alpha-adrenoreceptors in the brain stem. This action results in reduced sympathetic outflow from the central nervous system and in. The patch is usually worn for 1 week and then replaced Use Clonidine Patches as directed by your doctor. Change in skin color in the place where you applied a patch;. Larry Nichter Press the patch firmly in place for about 10 seconds to make sure it stays on. If the patch becomes loose, press the edges against the skin and cover the patch with one of the white adhesive Trazodone (Desyrel) 50 Mg Tablet covers Otsuka Abilify Sales that are included in the package If you are taking this medicine (clonidine patches) and have high blood pressure, talk with your doctor before using OTC products that may raise blood pressure. 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