She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Plaquenil does it cause bone loss Royal college of ophthalmologists hydroxychloroquine Plaquenil coupon website Retinal thinning in plaquenil toxicity Specifically, SD-OCT can detect loss of the perifoveal photoreceptor inner segment/outer segments line PIL At the macula, an ovoid appearance can appear described as “flying saucer” sign by Chen, et al 18 Toxicity were found to have significant outer retina disruption in the macula on SD OCT. Three patients with early HCQ toxicity and HVF 10-2 perifoveal defects were found to have loss of the perifoveal photoreceptor inner segment/outer segment IS/OS junction with intact outer retina directly under the fovea, creating the “flying saucer” sign. The “Flying Saucer” Sign on Spectral Domain Optical Coherence Tomography in Chloroquine Retinopathy Francisco J. Ascaso MD, PhD Lozano Blesa University Clinic Hospital and Instituto Aragonés de Ciencias de la Salud Zaragoza, Spain Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Flying saucer sign oct plaquenil Pigment dropout found in middle-aged man’s first eye exam, Open Access Full Text Article spectral domain optical. Is hydroxychloroquine safe to take while breastfeeding Sep 15, 2014 Chen E, Brown DM, Benz M, et al. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the “flying saucer” sign. Clin Ophthalmol. 2010 Oct 21;51-8. Is Damage Still Occurring? - Review of Optometry. The “Flying Saucer” Sign on Spectral Domain Optical.. Spectral domain optical coherence tomography as an.. Plaquenil maculopathy is an uncommon side effect of the systemic medication, Hydroxychrloroquine. This lecture will guide the optometrist in diagnosis and management of Plaquenil maculopathy. The course will review updated guidelines from the American Academy of Ophthalmology and discuss exciting new research utilizing OCT. Repeat 10-2 HVF testing demonstrated the dense paracentral scotomas. SD-OCT showed loss of the parafoveal inner/outer segment junction, thinning of the parafoveal outer nuclear layer, and a loss of the normal foveal depression, which is characteristic for hydroxychloroquine retinal toxicity Figure 3. Download Citation SD-OCT As screening test for hydroxychloroquine retinopathy The flying saucer sign Two asymptomatic women treated with hydroxychloroquine 200mg every day for 8 and 16.