Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Hydroxychloroquine or sulfasalazine What is the maximum dose of plaquenil Sle on plaquenil Hydroxychloroquine also called Renal clearance in rheumatoid arthritis patients taking PLAQUENIL for at least six months seemed to be similar to that of the single dose studies in volunteers, suggesting that no change occurs with chronic dosing. Range for renal clearance of unchanged drug was approximately 16 to 30% and did not correlate with creatinine clearance; therefore. The recommended adult dose for rheumatoid arthritis is 400-600 mg daily for 4-12 weeks followed by 200-400 mg daily. Systemic lupus erythematosus is treated with 400 mg once or twice daily for several weeks then 200-400 mg daily. Initial dose 400 mg 310 mg base orally 1 to 2 times a day; this dose may be continued for several weeks or months, depending on patient response. Maintenance dose 200 to 400 mg 155 to 310 mg base orally daily. Comments -Each dose should be taken with a meal or a glass of milk. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil dosage for ra Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria, Hydroxychloroquine Plaquenil Side Effects & Dosage for. Plaquenil rash side effectsChloroquin quinine For use in combination with methotrexate and sulfasalazine† for rheumatoid arthritis. Oral dosage. Adults. of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Close monitoring for evidence of methotrexate toxicity should be done. Plaquenil hydroxychloroquine sulfate dose, indications.. Hydroxychloroquine Dosage Guide with Precautions -. Treatments for Rheumatoid Arthritis. Dosage Hydroxychloroquine Plaquenil® is the drug of choice among antimalarials. Chloroquine is not commonly used because of greater toxicity on the eye. The usual dose of Plaquenil is 400mg/day but 600mg/day is sometimes used as part of an induction regimen. It may be prescribed as a single daily dose or in divided doses twice per day. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. Hydroxychloroquine dosage recommendations often ignored. 81% were women, and patients had been taking HCQ for an average of just over 6 years, primarily for rheumatoid arthritis or systemic lupus erythematosus. Nearly two-thirds had a high risk for retinal toxicity. Based on the 2011 recommendations from the AAO and ACR, 17% of the patients.