Chloroquine diphosphate salt lysosome inhibitor

Discussion in 'Plaquenil Generic' started by ProSpec, 24-Feb-2020.

  1. mdinc Guest

    Chloroquine diphosphate salt lysosome inhibitor


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Application. DNA intercalator. Also used to increase transfection efficiency. Chloroquine diphosphate salt has been used • in in vitro antiplasmodial assays • in transfection and infection assays • in autophagy inhibition • in differentiation of induced pluripotent stem iPS cells into cardiomyocytes • in flow treatment of infected blood. Several lysosomal inhibitors such as bafilomycin A1 BafA1, protease inhibitors and chloroquine CQ, have been used interchangeably to block autophagy in in vitro experiments assuming that they all primarily block lysosomal degradation. Chloroquine Diphosphate salt is a member of the quinolone family and a lysosomotropic agent accumulate inside the acidic parts of the cell. This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine diphosphate salt lysosome inhibitor

    Chloroquine diphosphate salt, 98%, Acros Organics Fisher., Chloroquine inhibits autophagic flux by decreasing.

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  3. Sigma-Aldrich offers a number of Chloroquine diphosphate salt products. View information & documentation regarding Chloroquine diphosphate salt, including CAS, MSDS & more.

    • Chloroquine diphosphate salt Sigma-Aldrich.
    • Chloroquine at Thomas Scientific.
    • Chloroquine - Wikipedia.

    Chloroquine diphosphate, apoptosis and autophagy inhibitor CAS 50-63-5, with 98% purity. Water soluble compound. Join researchers using our high quality biochemicals. Chloroquine diphosphate salt powder or crystals, 98.5-101.0% dry basis Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labeling of MRP by quinoline-based photoactive drug IAAQ N-4-1-hydroxy-2-dibut ylaminoethylquinolin-8- yl-4-azidosalicylamide. Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base. Inactive Ingredients colloidal silicon dioxide, dibasic calcium phosphate, hydroxypropylmethylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate80, pregelatinized starch.

     
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  5. smerust User

    Mefloquine dosing, indications, interactions, adverse. Medscape - Indication-specific dosing for mefloquine, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

    Chloroquine Uses, Side Effects, Dosage & Interactions
     
  6. xxlcars New Member

    Plaquenil eye problems Mayo Clinic Connect I was wondering if anyone experienced blurry vision on Plaquenil. I have been on Plaquenil for about a month. Every now and then I notice some of the words on the television are blurry, then there are other times my eyes are fine. Should this be a big concern? I

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