Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Benlysta vs plaquenil Is plaquenil used for osteoarthritis Will plaquenil help anemia Plaquenil 200mg side effects Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead. Clinical practice guidelines recommend use of combination DMARDs such as hydroxychloroquine plus methotrexate for patients with a disease duration less than 6 months and moderate disease activity and poor prognostic features and is an option for high disease activity and poor prognostic features. The fatigue is still considerable on some days, but overall I feel 110% better than I did. I was unable to work before taking these drug and now I am back to working full time and I spent this entire weekend enjoying my grandkids! I have also been able to step the prednisone bake to no more than 5 Mg every two days which is a big plus. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Is plaquenil safer than methotrexate DMARDs Disease-Modifying Antirheumatic Drugs – CreakyJoints, Plaquenil hydroxychloroquine sulfate dose, indications. Can i get plaquenil in australiaTreatment for allergic reaction to plaquenil Mar 21, 2014 Ok, here is a question that we all could probably use an answer to; Methotrexate or Plaquenil for CREST Scleroderma. I have read Plaquenil is better for Lupus but Methotrexate is better for Scleroderma. Doctor said either is fine, but she wants me to choose. What is your experience with either or both. I need reviews. Methotrexate or Plaquenil - Scleroderma - Inspire. Methotrexate and plaquenil - @Kristinsaba1988 - Scleroderma - 20151009.. Anyone used plaquenil and arava which is better? DailyStrength. Your doctor may prescribe methotrexate alone. or you may also take other drugs like aspirin, nonsteroidal anti-inflammatory drugs, low-dose steroids, or other disease-modifying antirheumatic drugs. When monotherapy with a synthetic DMARD isn’t working well enough, consider a triple combination of hydroxychloroquine, methotrexate, and sulfasalazine. It works better than a two-drug combination methotrexate with either drug. Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification.