It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Lupus medications chloroquine Plaquenil cancer If the maximum daily dosage recommendations are followed, the likelihood of toxicity from chloroquine or hydroxychloroquine is less than 1% the first five years of treatment. Corneal epithelial changes are usually reversible, but retinopathy caused by these agents are not. It is excreted by the kidney and liver, and is minimally removed during dialysis; therefore, persistent liver and renal dysfunction potentiate its toxicity. It has been postulated that the lower toxicity of HCQ compared with CQ may be due to the hydroxyl group limiting the ability of HCQ to cross the blood–retinal barrier 17. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Hydroxychloroquine liver toxicity Hydroxychloroquine Oral Route Description and Brand Names., Hydroxychloroquine-related retinal toxicity Rheumatology. Chloroquine drug adverse effects Hydroxychloroquine therapy has not been associated with liver function abnormalities and is an extremely rare cause of clinically apparent acute liver injury. Hydroxychloroquine is a derivative of chloroquine that has both antimalarial and antiinflammatory activities and is now most often used as an antirheumatologic agent in systemic lupus erythematosis and rheumatoid arthritis. Hydroxychloroquine - LiverTox - NCBI Bookshelf. Protecting your eyesight when taking Plaquenil Lupus.. Plaquenil Side Effects Common, Severe, Long Term -. Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Common side effects include vomiting, headache, changes in vision and muscle weakness. Severe side effects may include allergic reactions. It does not appear to be safe during The risk of retinal toxicity is dependent on several factors A daily dose of hydroxychloroquine 5.0 mg/kg using the patient's body weight. Severe renal impairment. Concomitant use of tamoxifen. Duration of use 5 years. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight.