Hi Dr V, I am at a crossroad of considering to go back on Plaquenil . A year ago I proposed to go off Plaquenil after being on it for 22 years. Plaquenil effects on liver Ocular toxicity plaquenil Chloroquine phosphate anemones The one thing that concerns me about the Plaquenil is the half life is about 50 days. So, after even just a couple weeks on it.would take you many months for it to leave your system. Also, you should get a baseline eye test before or shortly after starting the Plaquenil. And, then yearly exams after that to check for Retinopathy. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil is also indicated for the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus in adults, and for the treatment of acute and chronic rheumatoid arthritis in adults. • Postmarketing cases of life-threatening and fatal cardiomyopathy have been reported with use of Plaquenil and chloroquine. If I had joint or muscle aches, I took care of it by resting, Aleve and ice. At my recent eye exam the doctor mentioned I had reached the plaquenil toxicity level and that my retina cells could die (which do not regenerate! My proposal was based on the fact that I had not had any major inflamation that completely shut me down or keep me from being active. What is the half life of plaquenil Only Half of People with Lupus Adhere to Hydroxychloroquine., Hydroxychloroquine Plaquenil Cost of antimalarial drugs chloroquinePlaquenil skin side effects picturesHydroxychloroquine widely useSide effects of plaquenil and prednisonePlaquenil after gastric sleeve Plaquenil pla´kwĕ-nil trademark for a preparation of hydroxychloroquine, an antiinflammatory and antiprotozoal agent used for treatment of malaria, lupus erythematosus, rheumatoid arthritis, and giardiasis. Plaquenil definition of Plaquenil by Medical dictionary. Plaquenil hydroxychloroquine – New Warnings. Plaquenil - FDA prescribing information, side effects and uses. Pharmacokinetics Following a single 200 mg oral dose of PLAQUENIL to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Yes. The half life is 1-2 months. The half life is the time it takes for half of the drug to be eliminated from the body. So even after 2 months, it is still present. This means it continues to work during that time.