Hydroxychloroquine autophagy inhibitor

Discussion in 'Hydroxychloroquine Sulfate 200 Mg' started by pomogitedetyam, 17-Mar-2020.

  1. Zorga Guest

    Hydroxychloroquine autophagy inhibitor


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    The combination of temsirolimus TEM, an MTOR inhibitor, and hydroxychloroquine HCQ, an autophagy inhibitor, augments cell death in preclinical models. This phase 1 dose-escalation study evaluat. Hydroxychloroquine Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor TLR 7/9. Hydroxychloroquine, a hydroxy derivative of chloroquine, is an antimalarial agent which is also used as an anti-rheumatic drug. The neuroprotective potential of hydroxychloroquine and chloroquine remained controversial until recently a study showed that chloroquine exhibited an antiparkinsonian activity through Nurr1 modulation.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Hydroxychloroquine autophagy inhibitor

    Sirolimus and Autophagy Inhibition in Lymphangioleiomyomatosis, Hydroxychloroquine Sulfate Autophagy inhibitor Read.

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  6. Tumor cells require autophagy to remove misfolded proteins or damaged cellular organelles. SBI-0206965 was shown to suppress autophagy induced by mTOR inhibition. mTOR signaling is often hyperactive in many tumors and can drive proliferation, so mTOR inhibitors are being investigated as anticancer agents.

    • Autophagy Inhibitors - Autophagy Sigma-Aldrich.
    • Hydroxychloroquine antiparkinsonian potential Nurr1..
    • Mechanisms of action of hydroxychloroquine and chloroquine..

    Feb 26, 2020 Previous findings supported by the TSCRP suggested that mutated TSC1 and TSC2 suppress autophagy, allowing mutated cells to proliferate. In vitro studies found that administration of autophagy inhibitor hydroxychloroquine in combination with Sirolimus decreased survival of TSC2 deficient cells, and reduced the tumor size in mouse models. Hydroxychloroquine is in the antimalarial and 4-aminoquinoline families of medication. Hydroxychloroquine was approved for medical use in the United States in 1955. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. Hydroxychloroquine HCQ is a lysosomotropic autophagy inhibitor being used in over 50 clinical trials either alone or in combination with chemotherapy. Pharmacokinetic PK and pharmacodynamic PD studies with HCQ have shown that drug exposure in the blood does not correlate with autophagy inhibition in either peripheral blood mononuclear cells or tumor tissue. To better explain this PK/PD.

     
  7. neva Well-Known Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine Oral Route Description and Brand Names. Medicines for the Prevention of Malaria While Traveling. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION
     
  8. dombossin User

    Chloroquine Phosphate - WebMD Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver.

    Primaquine Oral Uses, Side Effects, Interactions.