Low-dose hydroxychloroquine role in porphyria

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  1. dmitrox New Member

    Low-dose hydroxychloroquine role in porphyria


    Estrogen use should be discontinued unless its need outweighs its adverse effects on porphyrin metabolism. After achievement of remission, estrogen therapies may be cautiously reinstituted; however, the duration of remissions may be shortened.

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    Iron chelators are less effective than phlebotomy or low dose hydroxychloroquine or chloroquine in treating individuals with PCT. However, these drugs may play a role in treating affected individuals in whom the use of the two front-line therapies is not possible, such as individuals with end stage renal disease who are on hemodialysis. CONCLUSIONS Hydroxychloroquine, 100 mg twice weekly, is as effective and safe as phlebotomy in patients with PCT, although noninferiority was not established. Given these results, higher-dose regimens of hydroxychloroquine, which have more side effects, do not seem justified. BACKGROUND & AIMS Porphyria cutanea tarda PCT is an iron-related disorder caused by reduced activity of hepatic uroporphyrinogen decarboxylase; it can be treated by phlebotomy or low doses of hydroxychloroquine.

    If symptoms recur, re-treatment can restore remissions. Remissions may last from several months to many years.

    Low-dose hydroxychloroquine role in porphyria

    Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in Treatment., Low-dose hydroxychloroquine is as effective as phlebotomy in treatment.

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  4. Porphyria Cutanea Tarda and Polymorphous Light Eruptions. Has been used in treatment of porphyria cutanea tarda†. 114 116 117 See Patients with Psoriasis or Porphyria under Cautions. Has been effective in some cases when used in the treatment of polymorphous light eruptions†. Hydroxychloroquine Sulfate Dosage and Administration Administration

    • Hydroxychloroquine Sulfate Monograph for Professionals -.
    • Low-dose hydroxychloroquine is as effective as phlebotomy..
    • Porphyria cutanea tarda a case report Journal of Medical Case..

    Porphyria cutanea tarda PCT is an iron-related disorder that results from reduced activity of hepatic uroporphyrinogen decarboxylase. Treatment options include phlebotomy or low doses of hydroxychloroquine. Porphyria cutanea tarda may appear for the first time in patients with end-stage renal disease after several months of long-term dialysis. Anuric individuals can be readily diagnosed by assaying a plasma or serum specimen for the characteristic elevated levels of polycarboxylated porphyrins. Dosing recommendations in porphyria cutanea tarda. In the treatment of porphyria cutanea tarda, hydroxychloroquine 100 mg should be prescribed twice weekly for one month, then 200 mg/day until plasma porphyrin levels are normal for at least a month.

     
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