Chloroquine phosphate during pregnancy

Discussion in 'Hydroxychloroquine 200mg' started by Agar, 05-Mar-2020.

  1. brukaro XenForo Moderator

    Chloroquine phosphate during pregnancy


    While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta.

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    Nov 25, 2019 Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm. Pregnant women will be monitored during pregnancy, and newborns will be assessed at birth and followed until they are approximately 14 weeks of age. Participants will be randomized to one of the following regimens Chloroquine approximately 1,500 mg base over 3 days, twice during pregnancy 2 tablets on Day 0. For P. vivax or P. ovale infections, primaquine phosphate and tafenoquine for radical treatment of hypnozoites should not be given during pregnancy. Pregnant patients with P. vivax or P. ovale infections should be maintained on chloroquine prophylaxis for the duration of their pregnancy. The chemoprophylactic dose of chloroquine phosphate is.

    Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area.

    Chloroquine phosphate during pregnancy

    Chloroquine Phosphate Bulk Uses, Side Effects, Interactions., Chloroquine for Malaria in Pregnancy - Full Text View.

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  3. Safety of chloroquine in chemosupression of malaria during pregnancy. A cohort of 169 births to women who were exposed throughout pregnancy to chloroquine 300 mg base once a week for chemosuppression of malaria was studied.

    • PDF Safety of chloroquine in chemosupression of malaria during pregnancy.
    • Treatment of Malaria Guidelines For Clinicians United..
    • DailyMed - CHLOROQUINE PHOSPHATE tablet.

    To the Editor— In the editorial "The Placental Barrier and Drugs" JAMA12 Oct 26 1964 reference is made to a paper by Hart and Naunton in the October, 1964, issue of the Archives of Otolaryngology 7, reporting on the effects in a woman given chloroquine phosphate during four of. Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. The chemoprophylactic dose of chloroquine phosphate is 300mg base =500 mg salt orally once per week. After delivery, for pregnant patients with P. vivax or P. ovale infections who do not have G6PD deficiency, subsequent treatment with primaquine phosphate or tafenoquine is needed, but will depend on breastfeeding. If not breastfeeding, either drug can be used.

     
  4. eguar XenForo Moderator

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  5. intop Well-Known Member

    Sarcoid Skin Lesions and Plaquenil - Sarcoidosis - Inspire Plaquenil hydroxychloroquine is as you noted an anti-malarial that is used for sarcoidosis. It appears to be fairly effective for patients with skin, eye, liver/spleen, lung, and kidney involvement.

    Experience of hydroxychloroquine in the treatment of.
     
  6. desx Moderator

    Common and Rare Side Effects for Plaquenil Oral Find information about common, infrequent and rare side effects of Plaquenil Oral.

    Hydroxychloroquine 'Probably Safe' in Pregnancy MDedge ObGyn