Listing a study does not mean it has been evaluated by the U. TNF-α, IL-1 and IL-6 are known to have primary roles in the pathogenesis of rheumatoid arthritis and other inflammatory diseases. Chloroquine pigmentation Chloroquine medscape Consequences of delayed therapy with second-line agents in rheumatoid arthritis a 3 year followup on the hydroxychloroquine in early rheumatoid arthritis HERA study. Tsakonas E1, Fitzgerald AA, Fitzcharles MA, Cividino A, Thorne JC, M'Seffar A, Joseph L, Bombardier C, Esdaile JM. Hydroxychloroquine is used in routine practice for treating synovitis in inflammatory arthritides such as RA, is used anecdotally as a treatment for OA and has been shown to be effective at reducing pain in pilot studies. Methods/design. HERO is an investigator-initiated, multicentre, randomized, double-blind, placebo-controlled trial. A total of 252 subjects with symptomatic hand OA will be recruited across primary and secondary care sites in the UK and randomized on a 11 basis to active treatment or placebo for 12 months. We examined the underlying mechanisms involved in the chloroquine-induced inhibition of cytokine production.. The anti-rheumatic drug chloroquine has been shown to inhibit TNF-α, IL-1 and IL-6 production from mononuclear phagocytes. Hera study hydroxychloroquine New considerations in monitoring for hydroxychloroquine., Hydroxychloroquine effectiveness in reducing symptoms of. Why use plaquenil for sclerodermaHydroxychloroquine us brand nameHydroxychloroquine liver toxicity alcoholHydroxychloroquine systemic sclerosisHydroxychloroquine elevated serum porphyrin Jul 25, 2012 The HERA Study Group A randomized trial of hydroxychloroquine in early rheumatoid arthritis. Am J Med. 1995; 98 2156–168. Effects of Hydroxychloroquine on Immune Activation and.. Hydroxychloroquine effectiveness in reducing symptoms of hand.. Chloroquine inhibits production of TNF-α, IL-1β and IL-6 from.. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. The United States Center for. Study protocol required hydroxychloroquine initiation or maintenance at 400 mg by 10 weeks of gestation for all participants. Additionally, investigators sought to determine if treatment would decrease the rate of recurrence below the historical standard, which Izmirly pointed out previously published research has suggested is 18%. Phase I/II Study of Hydroxychloroquine With Itraconazole With Biochemically Recurrent Prostate Cancer HITMAN-PC The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.