Hydroxychloroquine weight based dosing

Discussion in 'Generic Chloroquine' started by Devvver, 17-Mar-2020.

  1. Kintcurashvili Kachaber Well-Known Member

    Hydroxychloroquine weight based dosing


    Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid).

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    Dosing is usually much lower in children and infants depending on their body weight, usually 5 mg, calculated as base, per kilogram kg of body weight one 200 mg tablet = 155 mg base. Child dosages should never exceed adult dosages. To treat lupus, one or two tablets are usually taken once or twice a day. The molecular weight of hydroxychloroquine sulfate is 433.95, and molecular formula is C18H26ClN3O. H2SO4. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Dosing Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Using this formula, the dosage for a 150-pound person would be 443 mg/day, as one kilogram equals 2.2 pounds. Because HCQ is formulated as a 200 mg tablet, many people taking it for lupus will take two pills per day.

    It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015.

    Hydroxychloroquine weight based dosing

    ACR Actual-weight hydroxychloroquine dosing works in SLE, up., PLAQUENIL® HYDROXYCHLOROQUINE SULFATE TABLETS, USP

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  4. Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity.

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    The risk increases with a higher dose and longer therapy. Vision risks. Hydroxychloroquine is dosed according to body weight. The American Academy of Ophthalmology AAO currently defines an overdose of hydroxychloroquine as more than 5.0 milligrams mg per kilogram kg of body weight 1 kg equals 2.2 pounds or more than 400 mg a day. Let's dive in. Melton & Thomas describe the typical safe Plaquenil dosage this way The usual dosage is two 200mg tablets per day. This is generally a "safe" dose for patients having a lean body weight of at least 135 lbs. The generally-regarded safe dosage is 6.5mg/kg/qd, thus the 135 lb. safety threshold. Adherence to Weight-Based Dosing Guidelines in Patients Receiving Hydroxychloroquine for Rheumatoid Arthritis and Systemic Lupus Erythematosus Tara Skorupa 1 and Robert Shmerling 1, 1 Beth Israel Deaconess Medical Center / Harvard Medical School, Boston, MA

     
  5. FAI Moderator

    In some cases, they may not be available in every strength or form as the brand-name drug. Hydroxychloroquine Plaquenil and Hair Loss Is my. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. Plaquenil - FDA prescribing information, side effects and uses
     
  6. antihrist User

    Hydroxychloroquine Plaquenil Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.

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