Chloroquine phosphate synthesis

Discussion in 'Generic Chloroquine' started by Gorden, 19-Mar-2020.

  1. Exlo1d New Member

    Chloroquine phosphate synthesis


    Visit Stack Exchange My intuition tells me that the nitrogen in the ring is more nucleophilic than the exocyclic amine. All this is not very promising and any attempt to optimize this reaction is fighting problems you would not have if you had decided for a more reasonable and well-established alternative in the first! A quick-and-dirty electrostatic potential calculation using B88LYP/6-31G(d) on the PM3 geometry shows a large electron density (blue and violet) on the ring nitrogen and lower density (yellow) on the exocyclic amine: Are there conditions that might work? That would be the synthesis of chloroquine from 4,7-dichloroquinoline and 4-diethylamino-1-methylbutylamine, where both starting materials are available through well-known procedures.

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    Protein synthesis in situ by chloroquine in the culture, the parasite eukaryotic initiation factor 2a- eIF-2a is phospho- rylated in the parasite lysate to a greater extent than that observed in the control culture. Mar 22, 2018 [email protected] This feature is not available right now. Please try again later. Chloroquine Phosphate Injection. Compositions Contains chloroquine phosphate BP equivalent to chloroquine base 40 mg/mL. Pharmacological classification & ATC Classification P01BA01 - chloroquine ; Belongs to the class of aminoquinoline antimalarials.

    It's a pretty untypical approach to chloroquine and you didn't tell how you would synthesize 7-chloro-3-aminoquinoline and the secondary chloride. There is a good chance that the planned reaction will furnish a quarternary ammonium salt as a side product: The reaction will not necessary stop at this point.

    Chloroquine phosphate synthesis

    Chloroquine diphosphate ≥99%HPLC Selleck ATM/ATR., Pharmacology of Chloroquine - YouTube

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  6. Chloroquine, introduced into medicine in the 1940s, is a member of an important series of chemically related antimalarial agents, the quinoline derivatives. Chloroquine is administered orally as chloroquine phosphate. It also can be given by intramuscular injection as chloroquine hydrochloride.

    • Chloroquine drug Britannica.
    • General Preparation - Chloroquine Phosphate Injection..
    • Synthesis, Characterization and Complexation Behaviour of..

    Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Oct 01, 2018 Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base. Inactive Ingredients colloidal silicon dioxide, dibasic calcium phosphate, hydroxypropylmethylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate80, pregelatinized starch. Chloroquine might be getting new life as an antiviral treatment for the novel coronavirus that emerged in Wuhan, China in late 2019 and has infected some 25,000 people in more than 25 countries. For decades, the drug was a front-line treatment and prophylactic for malaria.

     
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