Chloroquine fansidar and mefloquine

Discussion in 'Generic Chloroquine' started by evro, 15-Mar-2020.

  1. runersq New Member

    Chloroquine fansidar and mefloquine

    “Presumptive treatment” without the benefit of laboratory confirmation should be reserved for extreme circumstances (strong clinical suspicion or severe disease in a setting where prompt laboratory diagnosis is not available). Once the diagnosis of malaria has been made, appropriate antimalarial treatment must be initiated immediately.

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    The treatment regimens for chloroquine-resistant P. vivax infections are quinine sulfate plus doxycycline or tetracycline, or, atovaquone-proguanil, or artemether-lumefantrine, or mefloquine. These treatment options are equally recommended. Mefloquine is now a widely used prophylaxis for chloroquine-resistant falciparum malaria. We emphasise the importance of careful reporting of side-effects if further deaths are to be prevented, as previously experienced with Fansidar. Mefloquine Mefloquine is an aminoquinoline similar to quinine which is used both for prophylaxis and treatment of malaria, it being effective against many chloroquine-resistant Plasmodium falciparum infections. Mefloquine resistance has become a growing problem with it use as monotherapy.

    The clinical status of the patient: Patients diagnosed with malaria are generally categorized as having either uncomplicated or severe malaria. Treatment should be guided by three main factors: infections, the urgent initiation of appropriate therapy is especially critical.

    Chloroquine fansidar and mefloquine

    The antimalarial drugs quinine, chloroquine and mefloquine., Fatal toxic epidermal necrolysis associated with mefloquine.

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  3. Pre-90s – Chloroquine, Maloprim Fansidar • Wide spread chloroquine and anti-folate resistant falciparum in region in mid 80s • Doxycycline 100mg daily – first line • Mefloquine 250 mg weekly – second line until 2006 – now 3rd line aka “drug of last resort” • Malarone Atovaquone 250 mg + proguanil

    • Malaria, Mefloquine and the ADF.
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    After the blood was obtained on day 0 the patient received orally either a single dose of Mefloquine HC1, 1500 mg, or two or three tablets of Fansidar. Each tablet of Fansidar contained 25 mg pyrimethamine and 500 mg sulphadoxine. The Mefloquine was provided by the Walter Reed Army Institute of Research and the Fansidar was purchased locally. Chloroquine/proguanil or sulfa drug-pyrimethamine combinations should be used in all other plasmodia infections. The major commercial manufacturer of mefloquine-based malaria treatment is Roche Pharmaceuticals, which markets the drug under the trade name "Lariam". Lariam is fairly expensive at around 3 € per tablet pricing of the year 2000. In one trial mefloquine was compared with chloroquine in 40 patients with Plasmodium vivax malaria and in the other one mefloquine was compared with MSP in 40 patients with P falciparummalaria. The former trial showed that both a single oral dose of 250 mg mefloquine and a single oral dose of 450 mg chloroquine base were highly effective in relieving symptoms of malaria and in clearing P vivax parasitaemia.

  4. VLR Well-Known Member

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  5. Smailov XenForo Moderator

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  6. RuB XenForo Moderator

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