The main finding in scleroderma is thickening and tightening of the skin and inflammation and scarring of many body parts, leading to problems in the lungs, kidneys, heart, intestinal system and other areas. Twins and family members of those with scleroderma or other autoimmune connective tissue diseases, such as lupus, may have a slightly higher risk of getting scleroderma. There is still no cure for scleroderma, but effective treatments for some forms of the disease are available. Children can also develop scleroderma, but the disease is different in children than in adults. Plaquenil and catching colds Chloroquine concentration to inhibit autophagy Bad side effects of hydroxychloroquine Plaquenil skin rash side effects Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. The United States Center for. I've had a CREST diagnosis for 10 years now and she mentioned at our last visit that she feels I don't have that, but have Sjogren's instead. Mind you I have no dry eyes, mouth, or anything else. And I consistently test positive with the anticentromere pattern. And I have the R, S, and T of CREST. I stopped Plaquenil eons ago prior to Cytokine testing and haven't needed to get back on it. While it is a good drug, it is a good drug for what it's indicated for and CREST syndrome, lupus, Sjogrens and other auto-immune conditions will benefit from it. As a reminder it will only work if taken over the long term. A great deal of research is also underway to find better treatments for scleroderma and, hopefully, someday a cure. Although the underlying cause is unknown, promising research is shedding light on the relationship between the immune system and scleroderma. Hydroxychloroquine for crest syndrome Plaquenil pros and cons - Sclero Forums MAIN - Sclero Forums, Plaquenil--used To Treat Crest? - Sclero Forums MAIN. Chloroquine sigma ready made CREST syndrome, also known as the limited cutaneous form of systemic sclerosis lcSSc, is a multisystem connective tissue acronym "CREST" refers to the five main features calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. CREST syndrome - Wikipedia. Plaquenil/ hydroxychloroquine Phoenix Rising ME / CFS Forums. Scleroderma Treatment Options Johns Hopkins Scleroderma Center. The cause isn’t known, but CREST syndrome limited scleroderma is believed to be an autoimmune disorder, in which your immune system turns against your body. The immune system in people with CREST syndrome appears to stimulate cells called fibroblasts to produce excess amounts of collagen, a key component of connective tissue. But the clear link between tryptophan and eosinophilia myalgia syndrome and the scleroderma-like disease associated with contaminated rapeseed oil ingestion raise the possibility that exposure to something in the environment could trigger scleroderma. Symptoms. The symptoms of scleroderma vary from person to person and can include This section of the Scleroderma FAQ is focused on standard treatment approaches that are designed either to target the overall disease process or to modify the disease in a way that can potentially improve more than one symptom, for example, bosentan Tracleer for skin ulcers and PAH.