It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Does plaquenil thin the blood Plaquenil user reviews Valtrex and plaquenil Half-life T ½ In a bioavailability study of 5 healthy participants receiving 1 oral and 1 intravenous IV dose of hydroxychloroquine sulfate 200 mg 155 mg base administered on separate occasions, the mean terminal elimination half-life of hydroxychloroquine, as calculated from blood data, was more than 40 days for both the oral and IV. Pharmacokinetics Following a single 200 mg oral dose of hydroxychloroquine sulfate tablets to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Half life of hydroxychloroquine sulfate Pharmacokinetics and Bioequivalence Study of Hydroxychloroquine Sulfate., DailyMed - HYDROXYCHLOROQUINE SULFATE tablet Plaquenil and mouth soresDoes hydroxychloroquine cause leukopeniaPlaquenil sun pharmaceuticalsQuit plaquenil breast cancer treatmentsPlaquenil and edema It is available in 200 mg tablets of hydroxychloroquine phosphate each containing 155 mg of hydroxychloroquine. 1 Although commonly used in the treatment of rheumatologic diseases, it is a rare source of overdose in the United States. However, life-threatening symptoms can occur within an hour of ingestion. Treatment of hydroxychloroquine overdose - ScienceDirect. Hydroxychloroquine MedlinePlus Drug Information. Hydroxychloroquine - Wikipedia. Half-Life 70–120 h. Nursing Implications. Assessment & Drug Effects. Monitor for therapeutic effectiveness; may not appear for several weeks, and maximal benefit may not occur for 6 mo. Do baseline and periodic ophthalmoscopic examinations and blood cell counts on all patients on long-term therapy. The absorption half-life was approximately 3 to 4 hours and the terminal half-life ranged from 40 to 50 days. The long half-life can be attributed to extensive tissue uptake rather than through decreased excretion. Peak plasma levels of hydroxychloroquine were seen in about 3 to 4 hours. Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.