Try refreshing the page, or returning to the homepage. If the problem continues, please visit our support portal. Plaquenil ringing in ears Hydroxychloroquine renal impairment Chloroquine hallucinations Chloroquine cancer 2015 Historically, patients with primary Sjögren syndrome have had few effective, biologic options, but ongoing clinical trials may offer promising new options. Worldwide, several drugs are being tested in small, randomized trials in the hopes that they may produce targeted treatment for specific manifestations of the disease. To systematically review and assess the efficacy and safety of hydroxychloroquine HCQ for treating primary Sjogren’s syndrome pSS. Five electronic databases Pubmed, EMBASE, Web of science, Ovid, Cochrane Library were searched for randomized controlled trials and retrospective or prospective studies published in English that reported the effect of HCQ on pSS. The subjective symptoms. BACKGROUND To systematically review and assess the efficacy and safety of hydroxychloroquine HCQ for treating primary Sjogren's syndrome pSS. METHODS Five electronic databases Pubmed, EMBASE, Web of science, Ovid, Cochrane Library were searched for randomized controlled trials and retrospective or prospective studies published in. HCQ blocks IFN activation, which is present in half of the p SS patients. HCQ is frequently used to treat primary SS (p SS), but evidence for its efficacy is limited. Randomized controlled trial hydroxychloroquine sjogren Hydroxychloroquine for Sjögren Syndrome, Is hydroxychloroquine effective in treating primary Sjogren’s. Plaquenil for wormsChloroquine cellular toxicityHydroxychloroquine and eyes In-Depth randomized controlled trial This study randomized 120 individuals with SS to receive hydroxychloroquine or placebo for 24 weeks and measured their numeric analog scales on three domains dryness, fatigue, and pain. The proportions of individuals in each group with at least a 30% reduction in at least 2 of 3 domains were compared. No benefit with hydroxychloroquine Plaquenil over placebo.. Is hydroxychloroquine effective in treating primary Sjogren's.. Hydroxychloroquine treatment for primary. Effects of Hydroxychloroquine on Symptomatic Improvement in Primary Sjogren Syndrome The JOQUER Randomized Clinical Trial Article in JAMA The Journal of the American Medical Association 3123249. Study design. The study is a single-centre, double blinding and 24-week randomized and controlled trial with two arms, in one of which, needles will be inserted into previously set acupoints while sham acupuncture for the other group. 120 patients with symptomatic pSS are randomly assigned to acupuncture or sham acupuncture groups in 11 ratio. Methods/Design. OA TREAT is an investigator-initiated, multicenter, randomized, double-blind, placebo-controlled trial. A total of 510 subjects with inflammatory and erosive hand OA, according to the classification criteria of the American College of Rheumatology ACR, with recent X-ray will be recruited across outpatient sites, hospitals and universities in Germany.