Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil toxicity guildeline Plaquenil maculopathy report Dark palate hydroxychloroquine Plaquenil retina screening guidelines Doctors generally recommend regular eye exams while on Plaquenil, so that early changes can be caught. Once abnormalities are discovered, toxicity has already occurred. While it may be reversible if caught early, hydroxychloroquine retinopathy is not always reversible. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible. Studies have shown that patients who have manifested with retinopathy have traces of Plaquenil metabolites in their erythrocytes, plasma, and urine even after 5 years of discontinuing the medication 1, 2, 3. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil use with retinopathy The risk of toxic retinopathy in patients on long-term., Retinal Physician - Hydroxychloroquine Maculopathy An Update. Hydroxychloroquine black box warningGive brand names of chloroquineDmards plaquenil methotrexate Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Plaquenil Uses, Dosage & Side Effects -. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. These data suggest that hydroxychloroquine retinopathy is more common than previously recognized, especially at high daily intake and with long durations of use or in the presence of kidney disease or concurrent tamoxifen therapy. Daily use of 5.0 mg/kg of real body weight or less is associated with a low risk for up to 10 years of use. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Improved vision screening tests and updated dosing guidelines are key to avoiding such complications.