While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I started the hydroxychloroquine medication a week ago and within the first day or two noticed a big difference in my pain and fatigue with major improvement SLE. Need eye exam yearly using plaquenil Hydroxychloroquine test for eyes I just want to do something to help. Does icing the painful joints help? Heat? I just feel so helpless. The dr doesn't want to increase the pain meds and until the Plaquenil starts to do its thing which I understand can take a while I feel like we're stuck and she has no choice but to suffer through it. Treating the Pain and Fatigue. If the patient has widespread pain and fatigue in Sjogren's, there is a significant chance that they also have lupus, rheumatoid arthritis RA or fibromyalgia. The diagnosis and treatment of lupus and RA are fairly straightforward. Nov 16, 2018 During my last visit, I told him I was struggling with fatigue, so he prescribed Plaquenil hydroxychloroquine. Plaquenil is an antimalarial medication that is also commonly prescribed for a variety of chronic illnesses. I take it to help combat fatigue, and the difference it makes is pleasantly surprising. While there is good clinical evidence demonstrating the drug’s efficacy in rheumatoid arthritis and lupus, there are very few studies looking at hydroxychloroquine as a treatment for Sjögren’s. Plaquenil (hydroxychloroquine) is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. Plaquenil help with fatigue Will you have Fatigue with Plaquenil - eHealthMe, Why There's More to Sjogren's Syndrome The Dr. Oz Show Biaxin and plaquenil lyme disease Plaquenil hydroxychloroquine helps inflammation, will that help with fatigue in sarcoidosis? Plaquenil hydroxychloroquine helps inflammation, will that.. Things that Changed My Life with Lupus Fatigue, Part 3. Treatment/Plaquenil -. May 25, 2010 Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. Side effects are all GI related for the first few weeks to a month, but are no longer a problem after your body adjusts to the med. I also grew my hair back quickly & fully within a year of starting Plaquenil. It is FANTASTIC for fatigue & pain. I am sick much less often than prior to starting Plaquenil hydroxychloroquine is the generic name." I have been on Plaquenil for years. It has not helped me with fatigue. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness.