B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Hydroxychloroquine olecranon bursitis Methotrexate plaquenil combination Cutaneous adverse reactions to hydroxychloroquine have been described, including acute generalized exanthematous pustulosis 11, 12, Stevens-Johnson syndrome 13, and toxic epidermal necrolysis 14–16. Here we report a case of hydroxychloroquine-induced erythema multiforme after 12 days of exposure in a 25 year old woman with lupus. Feb 19, 2020 SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The authors describe the first case of drug rash with eosinophilia and systemic symptoms syndrome caused by hydroxychloroquine treatment in a male patient affected by seronegative arthritis. Hydroxychloroquine-induced DRESS syndrome SpringerLink B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Hydroxychloroquine induced rash Hydroxychloroquine-induced inverse psoriasis BMJ Case., Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Can chloroquine abort pregnancyCan you break plaquenil in halfHydroxychloroquine ocular toxicityComo ayuda el plaquenil es el lupusIs hydroxychloroquine and meloxicam Yes. Hair bleaching, hair loss, skin pigmentation, rash and itching are recognized skin adverse reactions of plaquenil hydroxychloroquine. These reactions tend to be worse if a patient is taking other medications that have similar skin toxicity. Please consult a dermatologist to ensure skin lesions are not psoriatic because Plaquenil hydroxychloroquine use needs special precautions in. Plaquenil hydroxychloroquine 200mg is it causing itchy.. Hydroxychloroquine-induced DRESS syndrome SpringerLink. Identifying Drug-Induced Lupus - U. S. Pharmacist. S ir, Hydroxychloroquine is widely used in the treatment of rheumatoid arthritis and systemic lupus erythematosus, with very few reported side‐report the case of a 65‐yr‐old woman who developed Stevens–Johnson syndrome 2 weeks after commencing treatment with hydroxychloroquine. Within 8 months of treatment, with moderate clinical response, she developed the skin rash depicted in Fig. 1, after prolonged exposure to sunlight during gardening. At the beginning, the skin had an erythematous colour, but gradually turned into a dark-pigmented rash. Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. Objective To describe the clinical features and outcome of hydroxychloroquine HCQ-induced pigmentation in patients with systemic lupus erythematosus SLE.