Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Side effects of plaquenil on eyes All well and plaquenil Screening requires the use of tests, such as 10–2 visual fields and SD-OCT and other modern techniques, such as autofluorescence imaging and multifocal electroretinography, to demonstrate early retinal damage.” 1 Melles & Marmor. The Risk of Toxic Retinopathy in Patients on Long-term Hydroxychloroquine Therapy. In rare cases, Plaquenil can adversely affect the eyes, and patients taking this medicine should be seen by an ophthalmologist at least once a year. Leflunomide works. Visual field tests take a long time to complete and can be difficult for patients. A traditional 10-2 test takes at least 15 minutes per eye, and if a 24-2 is added, a patient is taking the tests. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Early plaquenil visual field Early hydroxychloroquine macular toxicity - Warner - 2001., DMARDs for Treating Rheumatoid Arthritis Aralen para que sirvePlaquenil weight loss how much did you losePlaquenil 200 in pregnancyWhat does aralen doDoes plaquenil affect immune system Early retinopathy has been defined as an acquired, persistent paracentral scotoma visualized on automated visual field testing without any observable fundus changes. 1 Reports have shown that the visual loss from HCQ toxicity is less likely to be reversible once fundus changes are present. 1,2,3 Although newer testing modalities, such as spectral domain-optical coherence tomography, fundus autofluorescenece, and multifocal electroretinogram, are now recommended as part of screening when. Humphrey visual field findings in hydroxychloroquine toxicity. Despite Plaquenil dosing recommendations, retinal toxicity.. Plaquenil Toxicity Screening - Retina Group of New York. Early signs visual field defects on 10-2 HVF usually paracentral, perifoveal and parafoveal thinning of the retina with loss of the inner/outer segment junction on SD-OCT, increased or decreased signal on autofluorescence, central/paracentral ERG depression on mfERG, +/- changes on Amsler grid, +/- subtle RPE changes, +/- decreased color vision We did not, however, observe any cases of HCQ retinopathy in which the visual field was normal but where morphological SD-OCT changes were detected. Therefore, a reliable visual field may be the most sensitive test for detecting early toxicity. However, fields are often unreliable, and SD-OCT has value in assisting detection in these cases. Today it is recommended that every single person on Plaquenil get a visual field 10-2 test, plus one of the three other highly sensitive screening tests the FAF fundus autofluorescence imaging, the SD-OCT spectral domain optical coherence, or the multifocal electroretinogram mfERG,” Thomas says.