Whats the dosage that causes plaquenil toxicity

Discussion in 'Canadian Pharmaceuticals Online' started by viruscmw, 13-Mar-2020.

  1. parafin Well-Known Member

    Whats the dosage that causes plaquenil toxicity


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

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    Plaquenil can produce pigment changes in the macula of the retina. The retina is the part of the back of the eye that you see with. The macula is the central part of the retina responsible for central fine vision. With Plaquenil related toxicity, the pigment in the macula can change and alter vision by producing blurring and distortion of objects. A daily dose of 6.5mg/kg ideal body weight places patients at higher risk, but a daily dose below this level did not preclude the patient from developing toxicity after many years of treatment. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor. Dose and duration. Both the daily and total cumulative dose can increase the risk of Plaquenil toxicity. “To min­imize this, the dose should be main­tained at less than 5.0 mg/kg per day for real body weight, rather than ideal weight,” said Dr. Mieler. The 400-mg dosage has traditionally been very popular, said Dr. Sarraf.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Whats the dosage that causes plaquenil toxicity

    Plaquenil Side Effects Common, Severe, Long Term -, Hydroxychloroquine Plaquenil Toxicity and Recommendations.

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  3. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except.

    • What Conditions does Plaquenil Treat? - WebMD.
    • Drug Toxicity to the Retina and Optic Nerve Are You Missing..
    • Hydroxychloroquine Plaquenil Toxicity and..

    Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Advanced hydroxychloroquine toxicity presents as a bullseye maculopathy. Since retinal toxicity is usually irreversible, early detection of retinal toxicity and cessation of the offending agent is the best treatment. Corneal toxicity presents as an intraepithelial deposition of the drug into the cornea, which rarely affects vision.

     
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    Systemic lupus erythematosus predominantly affects women and is more common in blacks. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. TREATMENT OF CHRONIC DISCOID LUPUS ERYTHEMATOSUS WITH. What are the treatment options for discoid lupus.
     
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    Plaquenil is the brand name for the prescription drug hydroxychloroquine. PLAQUENIL® Methotrexate vs Plaquenil Comparison - Why There's More to Sjogren's Syndrome The Dr. Oz Show
     
  6. Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health. Chloroquine phosphate or hydroxychloroquine sulfate Plaquenil can be used for prevention of malaria only in destinations where chloroquine resistance is not present see Chapter 2, Yellow Fever Vaccine & Malaria Prophylaxis Information, by Country. Prophylaxis should begin 1–2 weeks before travel to malarious areas.

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