Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Take plaquenil while healing leaky gut Hydroxychloroquine and skin discoloration Chloroquine resistant and sensitive areas Effect of chloroquine injection on early pregnancy Also, Plaquenil may have various systemic side effects that are not related to the eyes. These too are rare and include nerve weakness, hallucinations, psoriasis and changes in hair color. The eye complications are the most serious and worrisome. Ocular toxicity from hydroxychloroquine may be seen in two distinct areas of the eye the cornea and the macula. Plaquenil related eye complications are not common. Plaquenil can produce pigment changes in the macula of the retina. The retina is the part of the back of the eye that you see with. The macula is the central part of the retina responsible for central fine vision. With Plaquenil related toxicity, the pigment in the macula can change and alter vision by producing blurring and distortion of objects. Although they are uncommon, Plaquenil has side effects that may affect your eyes. Plaquenil and Your Eyes In some people, Plaquenil can cause a condition called hydroxychloroquine retinopathy, often referred to as bulls-eye maculopathy. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. What are symptoms of plaquenil eye problems Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at Risk., Conditions Plaquenil-related Eye Problems Eugene Eye Care Plaquenil antimalarial medicationsCirrus oct plaquenilPlaquenil tablets side effects An eye exam is recommended at the start of treatment to detect any existing vision problems; follow-up tests are needed to catch retinal damage in the earliest stages, before symptoms appear. If found later, damage to the eye may be irreversible, even if the medication is stopped. Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at.. Plaquenil Side Effects on Your Eyes and Vision. Are My Eye Issues Related to My Rheumatoid Arthritis?. Common side effects Nausea and diarrhea This can often can be combatted by taking Plaquenil with food or milk. Dizziness Precautions with this side effect Do not drive, use machinery. Cramps. Headache. Dry skin. Loss of appetite. Some of the medications used to treat rheumatoid arthritis, such as prednisone a corticosteroid and Plaquenil hydroxychloroquine, can actually trigger eye problems. “Plaquenil, on rare. Many eye problems in patients with lupus originate from the drugs doctors use to treat lupus itself. Three groups of medications prescribed for lupus patients are immunosuppressive drugs such as methotrexate and mycophenolate, antimalarials such as hydroxychloroquine Plaquenil®, and steroids.