In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Plaquenil withdrawl Plaquenil endometriosis The risk of hydroxychloroquine-related retinopathy associated with skin hyperpigmentation is unknown.3 The risk of eye toxicity increases sharply toward 1% after five to seven years of hydroxychloroquine use, or a cumulative dose of 1000 g.4 Overview of Hyper- and Hypopigmentaion in Scleroderma Systemic sclerosis SSc such as limited or diffuse scleroderma, can cause hyperpigmentation darkening and hypopigmention lightening of the skin, usually in the areas which have been affected by skin hardening. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells anemia. JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959)A, Bluish-green pigmentation on the legs in a patient with systemic lupus erythematosus without lupus lesions at the time of the skin biopsy. Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine and skin darkening Hydroxychloroquine Skin Support, Systemic Scleroderma Skin Involvement Hyperpigmentation and. Can you take tylenol with plaquenilIs plaquenil used to treat vasculitisChloroquine protocol for travelMost common side effects of hydroxychloroquine Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Hydroxychloroquine-Induced Pigmentation in Patients With.. Plaquenil and Skin hyperpigmentation - a real-world study. Summary Skin hyperpigmentation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Omniscan, and have Arteriogram. About 25% of patients receiving chloroquine or hydroxychloroquine for several years develop bluish-grey pigmentation on face, neck and sometimes lower legs and forearms Continuous long-term use may lead to blue-black patches, especially in sun-exposed areas Re Plaquenil and skin discoloration Reply #11 on April 21, 2009, PM Hyper-pigmentation is a possible side effect of chloroquine medications, chloroquine binds with melanin, causing patchy or mottled spots on areas of skin exposed to sunlight.