Hydroxychloroquine and skin darkening

Discussion in 'Canadian Pharmaceuticals Online' started by digriz, 18-Mar-2020.

  1. Hydroxychloroquine and skin darkening


    In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent.

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    The risk of hydroxychloroquine-related retinopathy associated with skin hyperpigmentation is unknown.3 The risk of eye toxicity increases sharply toward 1% after five to seven years of hydroxychloroquine use, or a cumulative dose of 1000 g.4 Overview of Hyper- and Hypopigmentaion in Scleroderma Systemic sclerosis SSc such as limited or diffuse scleroderma, can cause hyperpigmentation darkening and hypopigmention lightening of the skin, usually in the areas which have been affected by skin hardening. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells anemia.

    JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959)A, Bluish-green pigmentation on the legs in a patient with systemic lupus erythematosus without lupus lesions at the time of the skin biopsy. Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended.

    Hydroxychloroquine and skin darkening

    Hydroxychloroquine Skin Support, Systemic Scleroderma Skin Involvement Hyperpigmentation and.

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  6. Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others.

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    Plaquenil and Skin hyperpigmentation - a real-world study. Summary Skin hyperpigmentation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Omniscan, and have Arteriogram. About 25% of patients receiving chloroquine or hydroxychloroquine for several years develop bluish-grey pigmentation on face, neck and sometimes lower legs and forearms Continuous long-term use may lead to blue-black patches, especially in sun-exposed areas Re Plaquenil and skin discoloration Reply #11 on April 21, 2009, PM Hyper-pigmentation is a possible side effect of chloroquine medications, chloroquine binds with melanin, causing patchy or mottled spots on areas of skin exposed to sunlight.

     
  7. HNKNTOZzz Well-Known Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine phosphate has shown apparent efficacy in. Chloroquine - LiverTox - NCBI Bookshelf CDC - Malaria - Malaria Worldwide - How Can Malaria Cases.
     
  8. Ouroseo Guest

    This site uses cookies to improve performance by remembering that you are logged in when you go from page to page. A New Synthesis of Chloroquine Journal of the American. How experts plan to treat the new coronavirus Live Science Chloroquine Mechanism of action and resistance in malaria 2.
     
  9. Annetka Well-Known Member

    Protecting your eyesight when taking Plaquenil Lupus Foundation of. We can detect changes early enough to prevent any significant effect on vision, and stopping the medication at that point appears to halt progression of the changes.” Which annual screening tests to ask for “The message I want to get out is Pay a lot more attention to side effects of medication and any changes in vision,” Utterback says.

    Stopping plaquenil - Sclero Forums MAIN - Sclero Forums
     
  10. voronok Well-Known Member

    Scleroderma - Diagnosis and treatment - Mayo Clinic May 18, 2019 Diagnosis. Because scleroderma can take so many forms and affect so many different areas of the body, it can be difficult to diagnose. After a thorough physical exam, your doctor may suggest blood tests to check for elevated levels of certain antibodies produced by the immune system.

    Scleroderma - Wikipedia