Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil and yellow diarrhea Plaquenil high anion gap ketoacidosis Does hydroxychloroquine decrease human anti-chimeric antibody Plaquenile alcohol Plaquenil can produce pigment changes in the macula of the retina. The retina is the part of the back of the eye that you see with. The macula is the central part of the retina responsible for central fine vision. With Plaquenil related toxicity, the pigment in the macula can change and alter vision by producing blurring and distortion of objects. Mar 17, 2017 Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative to be able to spot any changes and to contact the patient's rheumatologist to notify them about the changes. The presentation goes over how to spot and what testing to perform to make sure there is no retinal toxicity. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil retinal toxicity night vision Despite Plaquenil dosing recommendations, retinal toxicity., Plaquenil Toxicity Screening Macula and Retina Institute c/o. Hydroxychloroquine side effects and alcoholPlaquenil malaria Toxicity causes a parafoveal or extramacular loss of photoreceptors and the retinal pigment epithelium layer RPE. End stage maculopathy causes a bull’s eye pattern of RPE loss as well as possible cystoid macular edema, loss of central and peripheral vision as well as night vision. Plaquenil - Eye Doctor MD. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil Side Effects on Your Eyes and Vision. Most patients do not experience many symptoms of retinal toxicity until it has progressed too far. Late stages include loss of visual acuity, peripheral vision and night vision. Patients who have been on Plaquenil longer than 5 years, are on a daily dose greater than 5mg/kg real body weight, have kidney problems or use the drug Tamoxifen may be at a higher risk for developing toxicity. In advanced cases of retinal toxicity from Plaquenil, there can be loss of visual acuity, peripheral vision, and night vision. Most documented cases of Plaquenil retinal toxicity are related to large cumulative lifetime doses over a period of many years. Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative to be able to spot any changes and to contact the patient's rheumatologist to notify them about the changes. The presentation goes over how to spot and what testing to perform to make sure there is no retinal toxicity.