I have been on plaquenil for over a year and a half and methotrexate since September. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes (used to be every 2 weeks). I have lupus which mainly affects my joints and skin. One affects your eyes more and one affects your liver more. I would appreciate any comments or advice from everyone. Wannabe Hi, I am on both methotrexate and plaquenil. Wannabe To Be Free To Roam Sorry to hear that you are having a lot of pain with your RA. Pregnancy category hydroxychloroquine How long does it take plaquenil to start working What is hydroxychloroquine 200 mg used for Cyclosporine was stopped and hydroxychloroquine 400 mg/day introduced. After a few weeks the SCLE lesions improved and so did arthralgia and psoriatic lesions, which became less inflamed and reduced in size. One month later, hydroxychloroquine was reduced to 200 mg/day, methotrexate was stopped and prednisone reduced to 5 mg/day. With Plaquenil, the possibility of permanent vision damage scares me. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. I've read elsewhere that Plaquenil is not as strong/effective in the treatment of early RA. With Methotrexate, the reports of nausea and possible liver damage are concerning. Hydroxychloroquine is commonly used alongside other disease-modifying drugs including methotrexate – especially for rheumatoid arthritis. However, some drugs can interact with hydroxychloroquine. Indigestion remedies for example, antacids including some over-the-counter preparations can stop hydroxychloroquine being absorbed. I wish you well with this decision and the results. Your chances of problems with the methotrexate are a bit larger. deductible (I am at about $2,500 - $3,000 right now). My rheumy recently added Imuran (instead of methotrexate). So, what do yall know about the side effects of both and the benefits of both? Hydroxychloroquin and methotrexate Anxiety, depression and suicidal ideation in patients with., Plaquenil vs Methotrexate rheumatoid Billing oct for plaquenilPlaquenil after gastric sleeve Was the plaquenil controlling your RA symptoms? The trouble is you lose hair on Methotrexate too. But after losing heaps when I first went on it, I have stabalised now, I have thinner hair but it still looks fine and healthy. If plaq was working for your symptoms I'd go back on it. If you feel like the RA is escallating then go for mtx. Methotrexate vs Plaquenil? -. Hydroxychloroquine Side-effects, uses, time to work. Does anyone take methotrexate and hydroxychloroquine.. Summary Drug interactions are reported among people who take Hydroxychloroquine sulfate and Methotrexate together. This study is created by eHealthMe based on reports of 5,663 people who take Hydroxychloroquine sulfate and Methotrexate from Food and Drug Administration FDA, and is updated regularly. What is Hydroxychloroquine, and What Does It Do? According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with can also reduce the incidence of joint damage, thus lessening the risk of developing a long-term disability from complications. Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Close monitoring for.