Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil hives Cadaver chloroquine how does it work Treatment of severe chloroquine poisoning The typical dose for hydroxychloroquine is 200-400mg per day and is based on a person’s body weight or if you are overweight, your ideal body weight. While hydroxychloroquine is considered a relatively safe medication, like all medications there are potential risks. Plaquenil has been a life-saving drug for me, quite literally. I was a mess in 2004-2005 and then a dr put me on Plaquenil, and in 3 weeks most of my symptoms had disappeared. Body aches increased often after eating. Very painful headaches during the day & at night headlights of other cars were unbearable. Days just stuck in bed. One day of Plaquenil changed my life - it gave me more energy, eliminated the headaches, subsided inflammation/swelling, nearly non-existent pain! Three months later still going strong. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. More energy on plaquenil Starting Plaquenil DailyStrength, Hydroxychloroquine Reviews Everyday Health Hydroxychloroquine irisPlaquenil arthritis medicineIncreasing plaquenil dosePlaquenil tylenol interaction May 25, 2010 It worked. I never noticed any more fatigue from the Plaquenil. However, I can totally relate to the fatigue and getting your kids off to school and not being able to do much else. I went through that as well. A year later I have more energy and am taking many more drugs to treat this RA. Is extreme fatigue a side effect of Plaquenil?. User Reviews for Hydroxychloroquine to treat. -. Plaquenil Side Effects Common, Severe, Long Term -. Apr 10, 2019 Plaquenil is sometimes given only once per week. Choose the same day each week to take this medicine if you are on a weekly dosing schedule. Take Plaquenil with a meal or a glass of milk. To prevent malaria Start taking Plaquenil 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay and for at least 8 weeks after you leave the area. OMG, I am experiencing this since doubling my Plaquenil dose just over a week ago, and am spending my days close to the toilet But honestly, I have a bit more energy and less joint pain. I am hoping the rumbly tumbly eases up soon! I am really grateful to have more than one toilet in the house! yikes. I completely agree with Lynnwood that plaquenil helps stop the progression of your disease, so the longer you wait the worse your Sjogren's becomes. Plaquenil is a fairly benign medication and was originally developed to protect against malaria. Later it was found to help autoimmune diseases. It can be months before you get relief with plaquenil.