Other times though, the cause of the shedding locks could be the medications used to treat arthritis. Fortunately, hair loss from arthritis medications is not a widespread complication. Plaquenil nausea vomiting Chloroquine phosohate Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. I've had RA for 5 years and took plaquenil for the first four years. Towards the end of that, I started having scalp rashes and lost a great deal of hair in patches. Dr. changed meds to Arava, which has caused severe skin irritation on my fingers, hands, and toes. I was taken off of Arava yesterday, and now have the choice of plaquenil or MTX. Once you discontinue the offending medication, or with time, the shedding of your hair should gradually resolve over six to nine months. While there is no specific treatment for hair loss that occurs due to medication except for discontinuing it, don't stop taking your medication until you consult with your physician. Methotrexate: The most commonly prescribed disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis, methotrexate is responsible for hair loss in about 1 to 3 percent of people. Still, if your hair is an important part of your identity, it’s not a small matter to you. Arava and plaquenil Disease-modifying Antirheumatic Drugs DMARDs, Methotrexate vs Plaquenil? - Plaquenil and the sunPlaquenil cumulative dose toxicityHydroxychloroquine retinaWhat dosages can you take of plaquenil for arthritis If certain medications are taken with Arava, drug interactions may occur. These reactions can alter the amount of the medications in your blood, potentially increasing your risk for side effects or decreasing the effectiveness of the medications. Arava Drug Interactions - Arthritis Home Page. Arthritis Medications May Cause Hair Loss. Taking Plaquenil for Rheumatoid Arthritis. I was diagnosed with RA 2 years ago. Started off taking methotrexate, plaquenil and a round of low dose prednisone. Did well until side affects of methtrexate became too much mostly nausea. My rheumatologist put me on arava and I've been doing well. Pain mostly hands, wrists, ankles & feet is mild to moderate but definitely manageable. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Learn about drug interactions between hydroxychloroquine oral and leflunomide oral and use the RxList drug interaction checker to check drug combinations.