Chloroquine mechanism of action slideshare

Discussion in 'Canada Pharmacy' started by Arendil, 20-Mar-2020.

  1. Homer Well-Known Member

    Chloroquine mechanism of action slideshare


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Aminoquinoline, excellent schizonticide, Antimalarial, amebicide, anti inflammatory and local irritant. Mechanism of Action of Chloroquine Malarial parasites digest their own haemoglobin and release highly toxic heme. This heme is used up by parasitic polymerase enzyme and converted to non toxic haemozoin. Since Chloroquine is. MECHANISM OF ACTION  Acts on trophozoites.  Has no effect on cysts.  Nitro group of metronidazole is reduced by protozoan leading to cytotoxic reduced product that binds to DNA and proteins resulting into parasite death.  is active against the invasive form in gut and liver.  The metronidazole metabolites are taken up into bacterial DNA, and form unstable molecules. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine mechanism of action slideshare

    Mode of action and mechanisms of resistance for., Antiprotozoal druga their mode of action - SlideShare

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  6. Chloroquine Mechanism of action and resistance in malaria 2 minutes Microbiology - Duration. 2 minutes Microbiology 6,387 views

    • Chloroquine - YouTube.
    • Chloroquine mechanism of drug action and resistance in..
    • Pharmacology - Antiprotozoals - SlideShare.

    Chloroquine Mechanism of action i. The parasite digests the host cell’s hemoglobin to obtain essential amino acids ii. The process releases large amounts of heme, which is toxic to the parasite iii. To protect itself the parasite ordinarily polymerizes the heme to nontoxic hemozoin, which is sequestered in. Stereoselectivity in chloroquine body disposition could be responsible for this discrepancy. Chloroquine binding to plasma proteins is stereoselective, favouring S+-chloroquine 67% vs 35% for the R-enantiomer. Hence, unbound plasma concentrations are higher for R−-chloroquine. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine. The drug chloroquine is bactericidal for Bacillus megaterium ; it inhibits DNA and RNA.

     
  7. jcccc XenForo Moderator

    Interferes with digestive vacuole function within sensitive malarial parasites by increasing the p H and interfering with lysosomal degradation of hemoglobin; inhibits locomotion of neutrophils and chemotaxis of eosinophils; impairs complement-dependent antigen-antibody reactions Incomplete and variable (~70% [range: 25 to 100%]) (Tett 1993) Hepatic; metabolites include bidesethylchloroquine, desethylhydroxychloroquine, and desethylchloroquine (Mc Chesney 1966) Urine (15% to 25% [Tett 1993]; as metabolites and unchanged drug [up to 60%, Mc Chesney 1966]); may be enhanced by urinary acidification Rheumatic disease: May require several weeks to respond ~40 days (Tett 1993) ~40%, primarily albumin (Tett 1993) Lupus erythematosus: Treatment of chronic discoid erythematosus and systemic lupus erythematosus in adults. Hydroxychloroquine Professional Patient Advice - Hydroxychloroquine Side Effects Common, Severe, Long Term. APO-Hydroxychloroquine hydroxychloroquine sulfate Drug.
     
  8. Exorcium Guest

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Massive chloroquine overdose--a survivor. Chloroquine MedlinePlus Drug Information
     
  9. magnus Moderator

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as.

    Hydroxychloroquine-Induced Retinal Toxicity - American.
     
  10. queen_latifah New Member

    CDC - Malaria - Travelers - Malaria Information and. Drug Resistance 2 Malaria Species 3 Recommended Chemoprophylaxis 4 Key Information Needed and Helpful Links to Assess Need for Prophylaxis for Select Countries; Namibia Present in the regions of Kavango East and West, Kunene, Ohangwena, Omusati, Oshana, Oshikoto, Otjozunjupa, and Zambezi. Rare cases in other parts of the country. No malaria in city of Windhoek. Chloroquine

    Drug resistance in malaria - World Health Organization