Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil mechanism of action in lupus Chloroquine resistant malaria cdc Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Symptoms of allergic reaction to generic of plaquenil Plaquenil allergy signs - Answers on HealthTap, Hydroxychloroquine Side Effects Common, Severe, Long Term. Plaquenil antimalarial drugChloroquine for cancerSide effects of chloroquine and proguanil Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Plaquenil Side Effects on Your Eyes and Vision. Plaquenil Oral Uses, Side Effects, Interactions.. Then I had an allergic reaction to the plaquenil - a rash all over my body, neck, arms and legs. I stopped taking it 1 week ago. All of my symptoms of lupus and sjogrens are coming back and I am feeling worse each day. I have had irregular hearbeats since I stopped taking the plaquenil - all day and night. Though rare, this drug may cause an allergic reaction. Symptoms can include hives; swelling; trouble breathing ; If you develop these symptoms, call 911 or go to the nearest emergency room. RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells.