Mechanism of resistance to chloroquine

Discussion in 'Canada Drugs Online' started by Lucky Drakon, 07-Mar-2020.

  1. elena_seoshina Well-Known Member

    Mechanism of resistance to chloroquine


    Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

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    Taken together, our data indicate that CQ effectively targets the lysosome to sensitise towards cell death but is prone to a glucose-dependent resistance mechanism, thus Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely. The mechanisms of resistance for amino‐alcohols quinine, mefloquine and halofantrine are still unclear. Epidemiological studies have established that the frequency of chloroquine resistant mutants varies among isolated parasite populations, while resistance to antifolates is highly prevalent in most malarial endemic countries.

    Although resistance to these drugs tends to be much less widespread geographically, in some areas of the world, the impact of multi-drug resistant malaria can be extensive. Has also developed resistance to nearly all of the other currently available antimalarial drugs, such as sulfadoxine/pyrimethamine, mefloquine, halofantrine, and quinine.

    Mechanism of resistance to chloroquine

    Molecular mechanisms involved in chloroquine resistance., Chloroquine - Wikipedia

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  4. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

    • Chloroquine - FDA prescribing information, side effects..
    • The mechanisms of resistance to antimalarial drugs in..
    • Malaria understanding drug resistance - BugBitten.

    Nomura T, Carlton JM, Baird JK, del Portillo HA, Fryauff DJ, Rathore D, et al. Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria. J Infect Dis. 2001; 153–61. Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than susceptible parasites, and this is thought to be the basis of their resistance. However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial. Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best.

     
  5. peter_p Well-Known Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine Plaquenil Side Effects & Dosage for. Chloroquine - Wikipedia Chloroquine - YouTube
     
  6. webprofy.biz Guest

    Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term.

    What can Hydroxychloroquine Plaquenil do to my eyes?
     
  7. alrogo Guest

    W A77 Aralen Phosphate 500 mg - W A77 Aralen Phosphate 500 mg Generic Name chloroquine. Pill with imprint W A77 is Pink, Round and has been identified as Aralen Phosphate 500 mg. It is supplied by Sanofi-Synthelabo Inc. Aralen Phosphate is used in the treatment of malaria; amebiasis; malaria prevention and belongs to the drug classes amebicides, antimalarial quinolines.

    Aralen Oral Uses, Side Effects, Interactions, Pictures.