Pigmentation can be either normal or abnormal discoloration of oral mucous membrane. The purpose of this review mainly focuses on the main oral pigmented lesions, in order to help the clinicians establish a better approach towards the patients with pigmented oral lesions and to provide thorough knowledge regarding such lesions for patient reassurance, early definitive diagnosis and prompt treatment. Ran out of hydroxychloroquine Why is hydroxychloroquine prescribed Plaquenil ara Quizzn is a young service that bears only one goal - to make the learning process as enjoyable, social, and easy as possible. It is a free application that has the ability to connect people that are eager to learn, share knowledge and just have fun. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. The pigmentation resolved in two patients following chloroquine withdrawal despite being substituted by hydroxychloroquine. Hence, hydroxychloroquine may score over chloroquine not only with reference to ocular toxicity 9, but also with reference to cutaneous toxic-ity, for its long term use in patients suffering from con- Pigmented lesions affecting the skin were not included in our review. Relevant data concerning oral pigmented lesions, clinical features and the possibility of malignant transformation of such lesions were reviewed thoroughly from pubmed literature published in English. Chloroquine oral pigmentation Drug-Induced Pigmentation Background, Pathophysiology, Etiology, Chloroquine Indications, Side Effects, Warnings - Plaquenil goodrx Jul 30, 2019 Applies to chloroquine compounding powder, injectable solution, oral tablet. Ocular. Maculopathy and macular degeneration may be irreversible. Irreversible retinal damage has been reported in patients receiving long-term or high-dose 4-aminoquinoline therapy. Retinopathy has been reported as dose related. Chloroquine Side Effects Common, Severe, Long Term -. Hyperpigmentation of the Skin Following Chloroquine Treatment.. Pigmented Lesions of the Oral Cavity Pocket Dentistry. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Aug 30, 2011 Given the history of long-term chloroquine use, the top clinical working diagnosis was drug-induced oral pigmentation caused by chloroquine phosphate. To confirm this, and rule out the possibility of melanoma, a surgical evaluation was requested and the patient then underwent an incisional biopsy Fig. 2. Antimalarial drug–induced oral hyperpigmentation is uncommon and is reported to occur on the hard palate, gingiva, lips, and buccal mucosa.15, 47 In a retrospective study, pigmentation of the buccal mucosa or the hard palate was seen in 10 patients 5% using chloroquine, but none in hydroxychloroquine, 50 and there are rare case reports of.